ABSTRACT
To identify and categorize various pathological changes seen in testicular biopsies of males with infertility and to compare the results with data from other local and international studies. All testicular biopsies from males with infertility received by the Pathology Department of King AbdulAziz University Hospital, Jeddah, in the period from January 2004 until May 2010 are reviewed and histopathologically classified into seven categories as follows: Normal spermatogenesis, hypospermatogenesis, germ cell maturation arrest [GCMA], Sertoli cell only syndrome, seminiferous tubule hyalinization, mixed and discordant patterns. One hundred testicular biopsies were identified in the computerized records of the Department of Pathology of King AbdulAziz University Hospital in the studied period. The age ranged from 22 to 70 years with a mean age of 24.5 years. The histopathological patterns were as follows: 14 [14%] cases were reported as normal spermatogenesis;[29, 29%] cases as hypospermatogesis; and 12 [12%] cases were reported as GCMA, mostly at the level of primary spermatocytes. The Sertoli cell only syndrome and the seminiferous tubule hyalinization categories were each reported in 16 cases [16%]. Nine cases [9%] showed a mixed pattern. Discordant pattern was seen in 5 [5%] cases. Our study showed that hypospermatogenesis is the commonest pattern in testicular biopsies taken from males with infertility in our region. This study supports the recommendation of bilateral testicular biopsies when investigating male infertility